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KMID : 0811720060100050251
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Korean Journal of Physiology & Pharmacology
2006 Volume.10 No. 5 p.251 ~ p.254
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Inhibition of Adenosine Triphosphate-stimulated Mucin Secretion from Airway Epithelial Cells by Schizandrin
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Heo Ho-Jin
Lee Hyun-Jae
Kim Cheol-Su
Bae Ki-Hwan
Kim Yeong-Shik
Kang Sam-Sik
Park Yang-Chun
Kim Yun-Hee
Seo Un-Kyo
Seok Jeong-Ho
Lee Choong-Jae
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Abstract
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Schizandrae Fructus has been used for controlling respiratory allergic or inflammatory diseases in folk medicine and their components, schizandrin, schizandrin-A and gomisin-A were reported to have diverse biological effects. In this study, we investigated whether schizandrin, schizandrin-A and gomisin-A affect adenosine triphosphate (ATP)-induced mucin secretion from cultured airway epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled using 3H-glucosamine for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on 3H-mucin secretion. The results were as follows: 1) schizandrin significantly inhibited ATP-induced mucin secretion; 2) However, schizandrin-A and gomisin-A did not affect ATP-induced mucin secretion, significantly. We conclude that schizandrin can inhibit ATP- induced mucin secretion by directly acting on airway mucin-secreting cells. Therefore, schizandrin should further be investigated for the possible use as mucoregulators in the treatment of inflammatory airway diseases.
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KEYWORD
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Airway, Mucin, Schizandrin
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